In Vitro Anti-SARS-CoV-2 Activities of Curcumin and Selected Phenolic Compounds

Since the COVID-19 pandemic in 2020, many reports have highlighted several potential anti-SARS-CoV-2 drug candidates, including phenolic compounds. Therefore, this study aimed to evaluate activity of nine common compounds found plants using vitro cellular infection model. The curcumin, quercetin, gallic acid, catechin, rutin, kaempferol, naringenin, coumaric acid and caffeic were evaluated on SARS-CoV-2-infected Vero E6 cells by a cytopathic effect (CPE)-based assay. human lung cells, A549 expressing ACE2 TMPRSS2, was RT-qPCR technique. S1-ACE2 interaction 3CL protease assays also performed for potent compound. Of compounds, only curcumin inhibited SARS-CoV-2 induced CPE (EC 50 13.63 µM) but with low selective index (SI) value. Interestingly, exhibited an EC 4.57 µM SI value 7.96. inhibitory activities observed. In conclusion, showed moderate activity. true as candidate could be further animal